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I've got a larger non SBS site and we discovered that a recent upgrade to GFI WebMonitor caused the AV updates to randomly stop to the servers. The site uses Trend Micro's OfficeScan product and we were experiencing an error message during the update cycle that suggested that the AV pattern file updates were corrupt.  We traced it back to the GFi WebMonitor software which was intercepting all downloads including the AV Pattern File updates.  To solve the problem simply add *.trendmicro.com to the Whitelist in the GFI console and Save Settings.  Now things work once more.